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                 Madan Lab 

      Allosteric Regulation of Protein Kinases and Protein Tyrosine  Phosphatases

We use biophysical, biochemical, and mathematical tools to study the function and regulation of signaling enzymes:  both Protein Kinases and Protein Phosphatases. Individual projects in the lab look to define conformational and/or dynamics-based allosteric patterns in kinase and phosphatase regulation. We use both computational and experimental biophysical tools to assess protein function and stability.